A Novel Biomanufacturing System to Produce Multi-Material Scaffolds for Tissue Engineering: Concept and Preliminary Results

摘要

To produce multi-material scaffolds for Tissue Engineering accurate techniques are needed in order to obtain three-dimensional constructs with clinically appropriate size and structural integrity. This paper presents a novel biomanufacturing system that can fabricate 3D scaffolds with precise shape and porosity which is achieved through the control of all fabrication modules by an integrated computational platform. The incorporation of a clean flow unit and a camera allows to obtain scaffolds in a clean environment and provides a monitoring tool to analyse constructs during the production, respectively. In this research work is demonstrated that the new system enables the fabrication of multi-material 3D structures using poly (e-caprolactone) and sodium alginate for potential use in Tissue Engineering applications.