Activities of Quinolones Against Obligately Anaerobic Bacteria

摘要

Quinolones are of clinical and scientific interest since their discovery based on the nalidixic acid in the earlyrn1960s. They are based on two types of ring structures, the quinolone nucleus and the naphthyridone nucleus. Nalidixicrnacid as the first discovered agent is a naphthyridone and has only a moderate activity against Gram-negative rods. Thernmodification of the quinolone and naphthyridone structures resulted in increasing activities of the quinolones againstrnGram-negative, Gram-positive, atypical and obligately anaerobic bacteria and mycobacteria. The quinolones are now dividedrninto four groups due to their different spectrum of activity. The first and second group of quinolones i.e. norfloxacin,rnciprofloxacin or ofloxacin have no or only little activity against obligately anaerobic bacteria. In contrast, the newerrnquinolones like sitafloxacin, clinafloxacin, trovafloxacin, moxifloxacin, gatifloxacin, garenoxacin and others like i.e.rnWCK 771 and ATB-492 have significant improved activities against anaerobes. Thus, these quinolones have been consideredrnfor the treatment of anaerobe and mixed infections. The present review provides an overview of the activities of quinolonesrnagainst obligately anaerobic bacteria as described by in vitro as well as in vivo studies.