The Molecular and Cellular Aspects of Arthritis Due to Alphavirus Infections Lesson Learned from Ross River Virus

摘要

Alphaviruses such as the Sindbis-group viruses, Scandinavian Ockelbo virus, the African Asian chikungunya virus, the African O'nyong-nyong virus, the South American Mayaro virus, and the Australasian Barmah Forest and Ross River viruses, are commonly associated with outbreaks of acute and persistent arthritis and arthral-gia in humans. The mechanisms by which these viruses cause arthritis/ arthralgia are poorly understood. This chapter summarizes our current understanding of viral arthritides using our newly developed mouse model of Ross River virus-induced joint and muscle inflammation.