Angiopoietin-2: a multifaceted cytokine that functions in bothn angiogenesis and inflammation

摘要

Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin-2 (Ang-2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang-2 is upregulated inmultiple inflammatory diseases and has been implicated in the direct control of inflammation-related signaling pathways. As a consequence of