Association of O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation with p53 Mutation Occurrence in Non-Small Cell Lung Cancer with Different Histology, Gender, and Smoking Status

摘要

O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been demonstrated to associate with the G:C→A:T transition mutation in the p53 gene of lung tumors. The purpose of this study is to clarify whether MGMT promoter methylation is not only associated with the shift from the G:C→A:T mutation in the p53 gene but also whether MGMT increases other mutation patterns in lung tumors.