DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer

C. Postma1† M. Koopman2† T. E. Buffart1 P. P. Eijk1 B. Carvalho1 G. J. Peters3 B. Ylstra1 J. H. van Krieken4 C. J. A. Punt2 and G. A. Meijer1*

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DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer

机译：原发性肿瘤的DNA拷贝数概况作为晚期大肠癌对化疗反应的预测因子

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Background: Colorectal cancer (CRC) is biologically a heterogeneous disease, which may affect response to drug therapy. We investigated the correlation of genome-wide DNA copy number profiles of primary tumors with response to systemic chemotherapy in advanced CRC.

机译：背景：大肠癌（CRC）在生物学上是一种异质性疾病，可能会影响对药物治疗的反应。我们调查了原发性肿瘤全基因组DNA拷贝数概况与晚期CRC对全身化疗反应的相关性。

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《Annals of Oncology》 |2009年第6期|p.1048-1056|共9页
作者
C. Postma1† M. Koopman2† T. E. Buffart1 P. P. Eijk1 B. Carvalho1 G. J. Peters3 B. Ylstra1 J. H. van Krieken4 C. J. A. Punt2 and G. A. Meijer1*;
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1Department of Pathology, VU University Medical Center, Amsterdam 2Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen 3Department of Medical Oncology, VU University Medical Center, Amsterdam 4Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands;

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1. DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer. [J] . Postma C, Koopman M, Buffart TE Annals of oncology: official journal of the European Society for Medical Oncology . 2009,第6期

机译：原发性肿瘤的DNA拷贝数分布作为晚期大肠癌对化疗反应的预测因子。
2. Gene expression profile of 5-fluorouracil metabolic enzymes in primary colorectal cancer: potential as predictive parameters for response to fluorouracil-based chemotherapy. [J] . Kinoshita M, Kodera Y, Hibi K, Anticancer Research: International Journal of Cancer Research and Treatment . 2007,第2期

机译：5-氟尿嘧啶代谢酶在原发性结直肠癌中的基因表达谱：潜在作为基于氟尿嘧啶的化疗反应的预测参数。
3. RAS/BRAF Circulating Tumor DNA Mutations as a Predictor of Response to First-Line Chemotherapy in Metastatic Colorectal Cancer Patients [J] . Jiannan Yao, Wanchun Zang, Yang Ge, Canadian journal of gastroenterology & hepatology. . 2018,第3期

机译：RAS / BRAF循环肿瘤DNA突变作为转移性结直肠癌患者对一线化疗反应的预测因子
4. Identifying genes associated with chemotherapy response in ovarian carcinomas based on DNA copy number and expression profiles [C] . Hsu Fang-Han, Serpedin Erchin, Hsiao Tzu-Hung, Genomic Signal Processing and Statistics (GENSIPS), 2011 IEEE International Workshop on . 2011

机译：根据DNA拷贝数和表达谱鉴定与卵巢癌化疗反应相关的基因
5. Generalized singular value decomposition (GSVD) comparison of patient-matched normal and tumor aCGH profiles reveals global copy-number alterations predicting glioblastoma multiforme survival. [D] . Sankaranarayanan, Preethi. 2013

机译：患者匹配的正常和肿瘤aCGH谱的广义奇异值分解（GSVD）比较显示出预测胶质母细胞瘤多形体存活的总体拷贝数变化。
6. Analysis of Response Evaluation Criteria in Solid Tumors reduction ratio of primary chemotherapy in unresectable advanced or recurrent colorectal cancer [O] . Shiho Kawagoe, Masahiro Nakano, Keita Uchino, -1

机译：不可切除的晚期或复发性大肠癌初次化疗实体瘤减少率的响应评价标准分析
7. ERCC1 Codon 118 Polymorphism Is a Predictive Factor for the Tumor Response to Oxaliplatin/5-Fluorouracil Combination Chemotherapy in Patients with Advanced Colorectal Cancer [O] . Jérôme Viguier, Valérie Boige, Catherine Miquel, 2005

机译：Ercc1 Codon 118多态性是对晚期结直肠癌患者的肿瘤反应的预测因素，肿瘤反应/ 5-氟尿嘧啶组合化疗

DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer

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