Influence of characteristics of Inhaled Fibres on Development of Tumours in the Rat Lung

摘要

The objective was to examine and quantify the influence of fibre dimensions, persistence in the lung, and dissolution and cell toxicity in vitro, on the risks of developing lung tumours in rats. Data were brought together from the studies carried out at the IOM under the Colt Fibre Research Programme, and from studies carried out in Switzerland and the USA under the Programme of the Thermal Insulation Manufacturers Association. In both studies, groups of Rats were exposed by inhalation to a range of airborne fibres.