Suppression of electroosmotic flow and prevention of wall adsorption in capillary zone electrophoresis using zwitterionic surfactants

摘要

Addition of zwitterionic surfactants such as dodecyldi- methyl(3-sulfopropyl)ammonium hydroxide, hexadecyldi- methyl(3-sulfopropyl) ammonium hydroxide, and coco (amidopropyl)hydroxyldimethylsulfobetaine(Rewoteric AM CAS U) to an electrophoretic buffer suppress the elec- troosmotic flow by 50-90/100. Onset of suppression occurs at approximately the critical micelle concentration of the surfactant.