Improved Chiral Separations Using a Polymerized Dipeptide Anionic Chiral Surfactant in Electrokinetic Chromatography: Separations of Basic, Acidic, and Neutral Racemates

摘要

Two polymeric chiral anionic surfactants [poly(sodium N-undecylenyl-L-valine) (poly-L-SUV) and poly(sodium N-undecylenyl-L-valine-valine) (poly-L-SUVV)] are com- pared as pseudostationary phases for chiral separations of basic, acidic, and neutral enantiomers. Parameters such as pH, concentration and type of background elec- trolyte, concentration of polymerized chiral surfactants, and injection size were studied to investigate the migration behavior and optimize the chiral resolution of several racemic analytes.