Tracing Origins of Complex Pharmaceutical Preparations Using Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry

摘要

A novel strategy to trace the origins of commercialnpharmaceutical products has been developed based onnthe direct chemical profiling of the pharmaceutical productsnby surface desorption atmospheric pressure chemicalnionization mass spectrometry (DAPCI-MS). Besides thenunambiguous identification of active drug components,nvarious compounds present in the matrixes are simultaneouslyndetected without sample pretreatment, providingnvaluable information for drug quality control and originndifferentiation. Four sources of commercial amoxicillinnproducts made by different manufacturers have beennsuccessfully differentiated. This strategy has been extendednto secerning six sources of Liuwei Dihuang Teapills,nwhich are herbal medicine preparations with extremelyncomplex matrixes. The photolysis status ofnchemical drug products and the inferior natural herdnmedicine products prepared with different processesn(e.g., extra heating) were also screened using the methodnreported here. The limit of detection achieved in the MSMS experiments was estimated to be 1 ng/g for amoxicillinninside the capsule product. Our experimental data demonstratenthat DAPCI-MS is a useful tool for rapid pharmaceuticalnanalysis, showing promising perspectives forntracking the entire pharmaceutical supply chain to preventncounterfeit intrusions.