Immediate Effect of Topical Budesonide on Allergen Challenge - induced Nasal Muscosal Fluid Levels of Granulocyte - Macrophage Colony - stimulating Factor and Interleukin -5

摘要

The nasal antiinflammatory effects produced by maintenance treat - ment with topical steroids include reduced production of cytokines. The present study explored nasal mucosal effects induced during The first 9 h after a single dose of topical budesonide. Nine subjects With allergic rhinitis due to birch or timothy pollen were given Budesonide (256 μg; Rhinocort Aqua) or placebo in a double - blind, Randomized, crossover (4 wk washout) manner.