Inhibition of Phosphodiesterase 4 Attenuates Airway Hyperresponsiveness and Airway Inflammation in a Model of Secondary Allergen Challenge

摘要

ew compared for the first time the therapeutic potential of a spe- cific phosphodiesterase 4 (PDE4) inhibitor, rolipram, wth anti-VLA-4 AND ANTI-il-5 in a model of secondary allergen exposure of previ- Ously sensitized and challenged mice. To address these issues, Mice were sensitized and challenged with ovalbumin (OVA) (pri- Mary challenge). Six weeks later, sensitized/challenged mice were Reexposed to OVA (secondary challenge) and airway response (re- Sistance [R_L] and dynamic compliance [Cdyn]) to inhaled metha- Choline was monitored.