Inhaled gentamicin reduces airway neutrophil activity and mucus secretion in bronchiectasis

摘要

To investigate whether aerosolized gentamicin (GM) prevents myeloperoxidase (MPO)-mediated ari- way injury and mucus hypersecretion, a short course of aerosol therapy (3 d) with GM 40 mg or 0.45/100 saline (saline) twice per day was conducted. Twenty-eight patients with bronchiectasis and mucus hypersecretion after adequate chest care and hydration were enrolled in a randomized, dou- ble-blind fashion. MPO levels in sputum collected on arising were determined by fluorometric assay at 655 nm before and after treatment.