Hypercapnic Acidosis May Attenuate Acute Lung Injury by Inhibition of Endogenous Xanthine Oxidase

摘要

Relative hypoventilation, involving passively --- or "permissively" - generated hypercapnic acidosis (HCA), may improve outcome by reducing ventilator-induced lung injury. However, the effects of HCA per se on pulmonary microvascular permeability(K_f,c) in noninjured or injured lungs are un- Known. We investigated the effects of HCA in the isolated buffer-perfused rabbit lung, under condi- Tions of (1) no injury; (2) injury induced by warm ischemia-reperfusion; and (3) injury induced by ad- Dition of purine and xanthine oxidase.