Polymorphisms of the Beta Chain of the High-Affinity Immunoglobulin E Receptor(FcεRI-β) in South African Black and White Asthmatic and Nonasthmatic Individuals

摘要

We used amplification refractory mutation system-polymerase chain reaction(ARMS-PCR) to docu- ment the prevalence of three mutations in the beta chain of the high-affinity IgE receptor(FcεRI-β): I181L, V183L, and E237G in a sample of black and white asthmatic and control subjects in South Af- Rica to determine whether these variants contribute to the enhanced lgE responses in these groups And also to determine whether the discrepancy in the prevalence of atopy in these groups could be Attributed to these variants, as whites tend to be more atopic than blacks.