Prediction of Clinical Severity and Outcome of Ventilator-associated Pneumonia: Comparison of Simplified Acute Physiology Score With Systemic Inflammatory Mediators

摘要

Systemic kinetics of three inflammatory mediators(bactericidal/permeability-increasing protein[BPI], soluble intercellular adhesion molecule[siCAM], and soluble E-selectin[sE-selectin])were studied during the development of ventilator-associated pneumonia(VAP)(n = 42), diagnosed on quantita- tive cultures of bronchoscopic samples. From a pool of collected samples, nested samples were used to measure mediators on Days -4, -2, 0, and + 2, relative to diagnosis. Correlations between sys- temic levels of mediators and clinical severity of infection(VAP with or without severe sepsis or septic shock) and patients outcome(mortality at Day 10 after diagnosis) were studied.