Alcohol and Risk of Breast Cancer by Histologic Type and Hormone Receptor Status in Postmenopausal Women: The NIH-AARP Diet and Health Study

摘要

Little is known about the association between alcohol and breast cancer by different tumor characteristics. Thenstudy consisted of 184,418 postmenopausal women aged 50–71 years in the National Institutes of Health-AARPnDiet and Health Study (1995–2003). Alcohol use, diet, and potential risk factors for cancer were assessed withna mailed questionnaire at baseline. The relative risks and 95% confidence intervals were estimated by using Coxnproportional hazards regression. Breast cancer cases and estrogen receptor and progesterone receptor statusnwere identified through linkage to state cancer registries. During an average of 7 years of follow-up, 5,461 breastncancer cases were identified. Alcohol was significantly positively associated with total breast cancer: Even a mod-nerate amount of alcohol (>10 g/day) significantly increased breast cancer risk. In a comparison of >35 g versus 0 gday, the multivariate relative risks were 1.35 (95% confidence interval (CI): 1.17, 1.56) for total breast cancer, 1.46n(95% CI: 1.22, 1.75) for ductal tumors, and 1.52 (95% CI: 0.95, 2.44) for lobular tumors. The multivariate relativenrisks for estrogen receptor-positive/progesterone receptor-positive, estrogen receptor-positive/progesteronenreceptor-negative, and estrogen receptor-negative/progesterone receptor-negative tumors were 1.46 (95% CI:n1.12, 1.91) for >35 g versus 0 g/day, 1.13 (95% CI: 0.73, 1.77) for >20 g versus 0 g/day, and 1.21 (95% CI:n0.79, 1.84) for >20 g versus 0 g/day, respectively. Moderate consumption of alcohol was associated with breastncancer, specifically hormone receptor-positive tumors.