Photo Quiz: Localized Rash After Skin Exposure to Cold Temperature

摘要

Diagnosis is based on history; presence of recurrent palpable purpura; and laboratory findings showing low complement levels, elevated rheumatoid factor, and high circulating cryoglobulin levels.4 The exact etiology of essential mixed cryoglobulinemia is unknown; however, it appears to be related to certain liver, autoimmune, and lymphoproliferative disorders.