The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports

L. LLANOS; R. MOREU; T. ORTIN; A. M. PEIRÓ; S. PASCUAL; P. BELLOT; C. BARQUERO; R. FRANCÉS; J. SUCH; M. PÉREZ-MATEO; J. F. HORGA; P. ZAPATER

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The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports

机译：上市前临床试验中发现的血清丙氨酸氨基转移酶水平升高与上市后发表的肝毒性病例报告之间存在相关性

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Aliment Pharmacol Ther 31, 1337–1345

机译：Aliment Pharmacol Ther 31，1337年至1345年

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《Alimentary Pharmacology & Therapeutics》 |2010年第12期|p.1337-1345|共9页
作者
L. LLANOS; R. MOREU; T. ORTIN; A. M. PEIRÓ; S. PASCUAL; P. BELLOT; C. BARQUERO; R. FRANCÉS; J. SUCH; M. PÉREZ-MATEO; J. F. HORGA; P. ZAPATER;
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Clinical Pharmacology Section, Hospital General Universitario, Alicante, Spain;

Clinical Pharmacology Section, Hospital General Universitario, Alicante, Spain;

Clinical Pharmacology Section, Hospital General Universitario, Alicante, Spain;

Clinical Pharmacology Section, Hospital General Universitario, Alicante, Spain|Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, Alicante, Spain;

Liver Unit, Hospital General Universitario, Alicante, Spain|CIBERehd, Instituto de Salud Carlos III, Madrid, Spain;

Liver Unit, Hospital General Universitario, Alicante, Spain|CIBERehd, Instituto de Salud Carlos III, Madrid, Spain;

Liver Unit, Hospital General Universitario, Alicante, Spain;

Liver Unit, Hospital General Universitario, Alicante, Spain|CIBERehd, Instituto de Salud Carlos III, Madrid, Spain;

Liver Unit, Hospital General Universitario, Alicante, Spain|CIBERehd, Instituto de Salud Carlos III, Madrid, Spain;

Liver Unit, Hospital General Universitario, Alicante, Spain;

Clinical Pharmacology Section, Hospital General Universitario, Alicante, Spain|Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, Alicante, Spain;

Clinical Pharmacology Section, Hospital General Universitario, Alicante, Spain|Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, Alicante, Spain|CIBERehd, Instituto de Salud Carlos III, Madrid, Spain;

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1. The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports. [J] . Llanos L, Moreu R, Ortin T, Alimentary pharmacology & therapeutics. . 2010,第12期

机译：在上市前临床试验中发现的血清丙氨酸转氨酶水平升高与上市后发表的肝毒性病例报告之间存在相关性。
2. Analysis of the safety evaluation for premarketing clinical trials of hemodialyzer and of postmarketing safety reports of hemodialyzer in Japan and the US: insights into the construction of a sophisticated premarketing evaluation [J] . Saito Masami, Iwasaki Kiyotaka Journal of artificial organs: The official journal of the Japanese Society for Artificial Organs . 2017,第1期

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3. Does turmeric/curcumin supplementation improve serum alanine aminotransferase and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease? A systematic review and meta-analysis of randomized controlled trials [J] . Goodarzi Reza, Sabzian Kamran, Shishehbor Farideh, Phytotherapy research: PTR . 2019,第3期

机译：姜黄/姜黄素补充是否改善了非酒精性脂肪肝病患者的血清丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平？随机对照试验的系统评价和荟萃分析
4. Dissimilarity Measures for Detecting Hepatotoxicity in Clinical Trial Data [C] . Matthew Eric Otey, Srinivasan Parthasarathy, Donald C. Trost International Conference on Data Mining . 2006

机译：检测临床试验数据中肝毒性的异化措施
5. Published reports describing clinical trials in off-label uses of drugs: Are they a valid source of knowledge? [D] . Vedula, Satyanarayana Swaroop. 2012

机译：已发表的报告描述了毒品的临床试验：他们是一个有效的知识来源吗？
6. The Effect of Acetaminophen on Serum Alanine Aminotransferase Activity in Subjects Who Consume Ethanol: A Systematic Review and Meta-analysis of Published Randomized Controlled Trials [O] . B Rumack, K Heard, J Green, -1

机译：对乙酰氨基酚对血清谷丙转氨酶活性的影响谁消耗乙醇主题的系统评价和发布随机对照试验的meta分析
7. The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports [O] . L. LLANOS, R. MOREU, T. ORTIN, 2010

机译：在预展现临床试验中检测到血清丙氨酸氨基转移酶水平之间的关系的存在和肝毒性案例报告

The existence of a relationship between increased serum alanine aminotransferase levels detected in premarketing clinical trials and postmarketing published hepatotoxicity case reports

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