Dendrimer-scaffod-based electron-beam patterning of biomolecules

摘要

A layer-by-layer approach for patterning biomolecules on dendrimer scaffolds using electron-beam lithography has been developed (see Figure). A self-assembled poly(ethylene glycol) monolayer is patterned with aldehyde-terminated polyamidoamine dendrimers to allow the covalent immobilization of aminated oligonucleotide probes.