Synthesis and characterization of organotitanium substituted heteropolytungstosilicates and their biological activity

摘要

Tris-, di-(organotitanium)substituted tungstosilicatesα.β-[(CpTi)_3(SiW_9O_37)]~7-andγ-[Cp- Ti)_2(SiW_10O_38)]~6-were prepared by the reaction of Cp_2TiCl_2(Cp=η~5-C_5H_5)withα.β-SiW_9O~9-_34(notedα.β- SiW_9),γ-SiWO~8-_36(notedγ-SiW_10). The products were characterized by means of elemental analysis, IR, ~h NMR, ~183 W NMR and polarography. ~183W NMR spectra of the complexes support the stoichiometry of the new heteropolyanions and the probable retention of the A-XW_9 orγ-SiW_10 units. And the organotitanium substi- tuted compounds showed promisiong in vitro antitumor activity in two of human tumor cell lines.