Presence of Magnetic Fluids Leads to the Inhibition of Insulin Amyloid Aggregation

摘要

Insulin amyloid aggregation caused serious problems in the treatment of diabetes by insulin injection or by insulin pumps. In vitro formation of insulin amyloid fibrils was investigated in presence of several types of magnetic fluids. Interaction of magnetic fluids with insulin amyloid aggregates led to decrease of insulin fibrillization. The inhibiting activities are affected by coating layer of studied magnetic fluids as well as by their physical properties (diameter, concentration of magnetic particles). The highest inhibiting efficiencies were detected for sterically stabilized magnetic fluids in saline solution (75%) and for magnetic fluids modified by dextran (80%).