Effects of total coumarins of Cnidium monnieri on bone density and biomechanics of glucocorticoids-induced osteoporosis in rats

摘要

AIM: To evaluate the effects of total coumarins from dried fruits of Cnidium monnieri (TCCM) on glucocorticoids (GC)-induced osteoporosis (OP) in rats. METHODS: Single photon absorptiometric and biomechanical character measurements of femurs were used. RESULTS: The bone density (BD) indices in proximal, middle, and distal segments in GC group were decreased by 12/100 (P<0.05), 14/100 (P< 0.05), and 12/100 (P<0.05), respectively vs control group. The BD on proximal, middle, and distal segments in GC-TCCM group were increased by 26/100 (P<0.01), 34/100 (P<0.01), and 31/100 (P< 0.01), respectively vs GC group. The biomechanical competence in femoral middle segments in GC group tended to decrease vs control group.