Involement of interleukin-2 in analgesia produced by coriolus versicolor polysaccharide peptides

摘要

Conclusion: The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in theMBH. Aim: To study the role of interleukin-2(IL-2)and Mediobasal hypothalamus(MBH)in analgesia Produced by Coriolus versicolor polysaccharide peptide (PSP). Methods: The IL-2 antiserum was injected icv or ip and the MHB was destroyed electrolytically. Results: PSP ig 1 g.kg~-1.d~-1 for 6 d increased the pain threshold in tail stimulation- vocalization test in rats.