Effect of histamine H_3-receptor antagonist clobenpropit on spatial memory of radial maze performance in rats

摘要

Intracerebroven- tricular(icv)injection of clobenpropit(50μg)amelio- rated memory impairment induced by scopolamine in both parameters of radial maze performance. The ameliora- tion induced by clobenpropit was angagonized by an H_3 agonist,(R)-α-methylhistamine(5-10μg). α-Fluo- romethylhistidine(10, 20 μg), a histidine decarboxylase inhibitor, also effectively reversed clobenpropit-induced ameliorating effects. The brain his- Tamine H_3-receptor antagonists are highly related to the Spatial memory, and this action may be due to cholinergic Neurons.