Inhibition of experimental cirrhosis in rats by HD-03

摘要

Administration of TAA at a dose of 50 mtg/kg po for 90 d resulted in a sig- Nificant derangement of serum[serum glutamic pyruvate Transaminase(SGPT), serum glutamic oxaloacetate Transaminase(SGOT), alkaline phosphatase(ALP), al- Bumin and bilirubin] and hepatic(triglycerides, protein, Hydroxyproline, collagen and glycogen)biochemical pa- Rameters. Histopathological evaluation of liver sections Following TAA-intoxicated of cirrhosis. The responses such as membrane stabilization, Hepatocellular regeneration, and inhibition of collagen Formation are the contributing factors in the correction of TAA-induced cirrhosis by HD-03.