Salvianolic acid B inhibits fibril formation and neurotoxicity of amyloid beta-protein in vitro

摘要

Following incubation at 25 deg. C for 30 h, A-beta (1-40)(100mg/L)aggregated and formed fibrils SalB 10-100 nmol/L completely prevented the fibril formation within 30 h. Extension of amyloid fibrils in- creased with prolonging the incubation time. SalB inhib- ited the fibril formation process during this period. SalB could inhibit A- beta aggregation and fibril formation, as well as direct- ly inhibit the cellular toxicity of aged A-beta towards PC12 cells.