Methylprednisolone caused an increase in death after head injury

摘要

The first patient was enrolled in April 1999. In May 2004, recruitment was stopped. 2-week all-cause mortality was greater in patients who received methylprednisolone than in those who received placebo (Table). Preplanned subgroup analysis based on time from injury to randomization ( 1 h, > 1 to 3 h, or > 3 to 8 h) and severity of injury (GCS mild [13 to 14], moderate [9 to 12], or severe [3 to 8]) showed that groups did not differ for mortality according to time since injury (P = 0.05) or severity of injury (P = 0.22).