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Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain

机译：长期释放羟考酮和纳洛酮联合治疗非癌性慢性疼痛的长期疗效和安全性

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Objective:The aim of this study was to assess safety and efficacy of fixed combination oxycodone prolonged release (PR)aloxone PR in terms of both analgesia and improving opioid-induced bowel dysfunction (OIBD) and associated symptoms, such as opioid-induced constipation (OIC), in adults with chronic non-cancer pain.

机译：目的：本研究旨在评估固定组合羟考酮缓释（PR）/纳洛酮PR在镇痛和改善阿片类药物引起的肠功能障碍（OIBD）以及相关症状（如阿片类药物引起的便秘）方面的安全性和有效性（OIC），患有慢性非癌性疼痛的成年人。

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期刊名称 Wiley-Blackwell Online Open
作者
A Sandner-Kiesling; P Leyendecker; M Hopp; L Tarau; J Lejcko; W Meissner; P Sevcik; M Hakl; R Hrib; R Uhl; H Dürr; K Reimer;
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年(卷),期 -1(64),6
年度 -1
页码 763–774
总页数 12
原文格式 PDF
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1. 羟考酮/纳洛酮控释片与羟考酮控释片治疗韩国癌性疼痛患者的疗效及安全性的随机对照研究 [J] . Kyung-He Lee, Min Kyoung Kim, Yong Sang Hong, 癌症（英文版） . 2018,第005期
2. Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain. [J] . Sandner Kiesling A, Leyendecker P, Hopp M, International journal of clinical practice . 2010,第6期

机译：长期疗效和联合延长释放羟考酮和纳洛酮的长期疗效和安全性在非癌症慢性疼痛中的管理中。
3. Efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of moderate/severe chronic non-malignant pain: results of a prospectively designed pooled analysis of two randomised, double-blind clinical trials [J] . Oliver L?wenstein, Petra Leyendecker, Eberhard A Lux, BMC Pharmacology and Toxicology . 2010,第1期

机译：缓释羟考酮和纳洛酮联合治疗中度/重度慢性非恶性疼痛的疗效和安全性：两项随机，双盲临床试验的前瞻性汇总分析结果
4. Long-term safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate-to-severe chronic cancer pain [J] . Ahmedzai Sam H., Leppert Wojciech, Janecki Marcin, Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer . 2015,第3期

机译：羟考酮/纳洛酮的长期安全性和疗效延长释放片剂中度至重度慢性癌痛的患者
5. INTEGRATIVE MANAGEMENT FOR CHRONIC PAIN; HOW TO COMBINE ACUPUNCTURE WITH OTHER TREATMENT MODALITES FOR RATIONAL PAIN MANAGEMENT IN DOGS AND CATS [C] . International Congress on Veterinary Acupuncture . 2018

机译：慢性疼痛的综合管理;如何将针灸与其他治疗方式结合在狗和猫的合理疼痛管理中
6. The influence of pain self-management education on the prevalence of opioid prescription among patients with chronic non-cancer pain: An agent-based modeling simulation. [D] . Samuel-Ojo, Catherine O. 2015

机译：疼痛自我管理教育对慢性非癌性疼痛患者中阿片类药物处方的影响：基于代理的建模仿真。
7. Efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of moderate/severe chronic non-malignant pain: results of a prospectively designed pooled analysis of two randomised double-blind clinical trials [O] . Oliver Löwenstein, Petra Leyendecker, Eberhard A Lux, 2010

机译：缓释羟考酮和纳洛酮联合治疗中度/重度慢性非恶性疼痛的疗效和安全性：两项随机双盲临床试验的前瞻性汇总分析结果
8. Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain [O] . Sandner-Kiesling, A, Leyendecker, P, Hopp, M, 2010

机译：长期释放羟考酮和纳洛酮联合治疗非癌性慢性疼痛的长期疗效和安全性

Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain

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