Pathological significance and prognostic role of microvessel density evaluated using CD31 CD34 and CD105 in prostate cancer patients after radical prostatectomy with neoadjuvant therapy

摘要

BACKGROUNDNeoadjuvant hormonal therapy (NHT) is performed to improve the outcome in organ-confined prostate cancer. However, there is little information regarding the relationship between angiogenesis and NHT. The aim of this study was to identify a suitable method to evaluate the angiogenic status of tissue, and to determine the prognostic value of this method for biochemical recurrence in patients who had undergone radical prostatectomy after NHT.