Intrinsic properties of germinal center‐derived B cells promote their enhanced class switching to IgE

摘要

BackgroundResearch on the origins and development of human IgE‐expressing (IgE⁺) cells is required for understanding the pathogenesis of allergy and asthma. These studies have been thwarted by the rarity of IgE⁺ cells in vivo and the low frequency of class switch recombination (CSR) to IgE ex vivo. To determine the main source of IgE⁺ cells, we investigated the relation between the phenotypic composition of tonsil B cells and the CSR to IgE ex vivo.