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A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT‐birch pollen extract for the treatment of allergic rhinitis: results of a phase II study

机译：DBPC随机试验确定SLIT桦树花粉提取物治疗过敏性鼻炎的最佳有效和安全剂量：II期研究结果

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摘要

BackgroundSublingual immunotherapy (SLIT) is a potential efficacious and safe treatment option for patients with respiratory, IgE‐mediated allergic diseases. A combined tolerability, dose‐finding study with a sublingual liquid birch pollen preparation (SB) was conducted.

机译：背景舌下免疫疗法（SLIT）对于患有呼吸道，IgE介导的过敏性疾病的患者是一种有效而安全的潜在治疗选择。进行了舌下液体桦树花粉制剂（SB）的耐受性，剂量确定性研究。

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期刊名称 Wiley-Blackwell Online Open
作者
O. Pfaar; E. van Twuijver; J. D. Boot; D. J. E. Opstelten; L. Klimek; R. van Ree; Z. Diamant; P. Kuna; P. Panzner;
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年(卷),期 -1(71),1
年度 -1
页码 99–107
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
allergen immunotherapy birch pollen dose finding nasal provocation sublingual immunotherapy;

机译：过敏原免疫治疗;桦木花粉;剂量寻找;鼻激发;舌下免疫治疗;

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1. A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study [J] . Pfaar O., van Twuijver E., Boot J. D., Allergy . 2016,第1期

机译：DBPC随机试验，用于确定SLIT桦树花粉提取物治疗过敏性鼻炎的最佳有效和安全剂量：II期研究的结果
2. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: Results from a randomized, double-blind, placebo-controlled phase III trial [J] . Demoly Pascal, Emminger Waltraud, Rehm Dorte, The Journal of Allergy and Clinical Immunology . 2016,第2期

机译：服用2剂SQ HDM SLIT片剂可有效治疗屋尘螨引起的过敏性鼻炎：一项随机，双盲，安慰剂对照的III期临床试验的结果
3. AGILE-ACCORD: A Randomized, Multicentre, Seamless, Adaptive Phase I/II Platform Study to Determine the Optimal Dose, Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial [J] . Gareth Griffiths, Richard Fitzgerald, Thomas Jaki, Trials . 2020,第1期

机译：Agile-Accord：随机，多期中心，无缝，自适应相I / II平台研究，以确定多个候选药物治疗Covid-19的最佳剂量，安全性和功效：随机平台的研究方案的结构化概述审判
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Treatment of allergic rhinitis using a Chinese herbal formula Shi -Bi -Lin (SBL): Animal study, in vitro study and clinical trial [D] . Zhao, Yu 2005

机译：使用中草药配方石必琳（SBL）治疗变应性鼻炎：动物研究，体外研究和临床试验
6. AGILE-ACCORD: A Randomized Multicentre Seamless Adaptive Phase I/II Platform Study to Determine the Optimal Dose Safety and Efficacy of Multiple Candidate Agents for the Treatment of COVID-19: A structured summary of a study protocol for a randomised platform trial [O] . Gareth Griffiths, Richard Fitzgerald, Thomas Jaki, -1

机译：AGILE-ACCORD：确定多候选药物治疗COVID-19的最佳剂量安全性和有效性的随机多中心无缝自适应I / II阶段平台研究：针对随机平台的研究方案的结构摘要试用
7. A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT-birch pollen extract for the treatment of allergic rhinitis: results of a phase II study [O] . Pfaar, O., van Twuijver, E., Boot, J. D., 2016

机译：DBPC随机试验，用于确定SLIT桦树花粉提取物用于治疗过敏性鼻炎的最佳有效和安全剂量：II期研究的结果

A randomized DBPC trial to determine the optimal effective and safe dose of a SLIT‐birch pollen extract for the treatment of allergic rhinitis: results of a phase II study

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