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Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials

机译：利拉鲁肽3.0 mg用于体重管理的神经精神安全性：随机对照2期和3a期试验的结果

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AimsLiraglutide, a GLP‐1 receptor agonist, regulates appetite via receptors in the brain. Because of concerns regarding the potential of centrally‐acting anti‐obesity medications to affect mental health, pooled neuropsychiatric safety data from all phase 2 and 3a randomized, double‐blind trials with liraglutide 3.0 mg were evaluated post hoc.

机译：AimsLiraglutide是一种GLP-1受体激动剂，可通过大脑中的受体调节食欲。由于担心中枢性抗肥胖药可能会影响心理健康，因此特设2阶段和3a阶段的随机，双盲试验联合利拉鲁肽3.0μmg收集神经精神科安全性数据。

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期刊名称 Wiley-Blackwell Online Open
作者
Patrick M. ONeil; Vanita R. Aroda; Arne Astrup; Robert Kushner; David C. W. Lau; Thomas A. Wadden; Jason Brett; Ana‐Paula Cancino; John P. H. Wilding;
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作者单位

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年(卷),期 -1(19),11
年度 -1
页码 1529–1536
总页数 8
原文格式 PDF
正文语种
中图分类
关键词
antiobesity drug GLP‐1 analogue liraglutide obesity therapy randomized trial;

机译：抗肥胖药;GLP-1类似物;利拉鲁肽;肥胖症治疗;随机试验;

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1. Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials [J] . ONeil Patrick M., Aroda Vanita R., Astrup Arne, Diabetes, obesity & metabolism . 2017,第11期

机译：Neuropsychiatric安全与Liraglutide 3.0 mg重量管理：随机控制阶段2和3A试验结果
2. Efficacy and safety of liraglutide 3.0mg for weight management are similar across races: subgroup analysis across the SCALE and phase II randomized trials [J] . Ard J., Cannon A., Lewis C. E., Diabetes, obesity & metabolism . 2016,第4期

机译：利拉鲁肽3.0mg在体重控制方面的功效和安全性在各个种族中相似：SCALE和II期随机试验的亚组分析
3. Efficacy and Safety of Liraglutide 3.0 mg in Individuals With Overweight or Obesity and Type 2 Diabetes Treated With Basal Insulin: The SCALE Insulin Randomized Controlled Trial [J] . Diabetes care . 2020,第5期

机译：Liraglutide 3.0毫克在具有超重或肥胖的个体中的疗效和安全性，并用基础胰岛素治疗2型糖尿病：规模胰岛素随机对照试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Hypotensive resuscitation versus standard fluid resuscitation for the management of trauma patients in hemorrhagic shock: The safety phase of a randomized controlled trial. [D] . Morrison, C. Anne. 2009

机译：低血压复苏与标准液体复苏在失血性休克中对创伤患者的处理：一项随机对照试验的安全性阶段。
6. Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials [O] . O'Neil, PM, Aroda, VR, Astrup, A, 2017

机译：利拉鲁肽3.0 mg用于体重管理的神经精神安全性：随机对照2期和3a期试验的结果

Neuropsychiatric safety with liraglutide 3.0 mg for weight management: Results from randomized controlled phase 2 and 3a trials

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