No association between head injury with loss of consciousness and Alzheimer disease pathology—Findings from the University of Manchester Longitudinal Study of Cognition in Normal Healthy Old Age

摘要

ObjectivesHead injury with loss of consciousness (HI‐LOC) is a common occurrence. Some studies have linked such injuries with an increased risk of Alzheimer disease (AD). However, recent large clinicopathologic studies have failed to find a clear relationship between HI‐LOC and the pathological changes associated with AD. The present study aims to further investigate the relationship between HI‐LOC and AD pathology in the elderly.