Playback of 50-kHz ultrasonic vocalizations overcomes psychomotor deficits induced by sub-chronic haloperidol treatment in rats

摘要

Experimental design of behavioral tests to assess the effect of 50-kHz USV on psychomotor deficits induced by sub-chronic haloperidol treatment. During phase 1, behavioral activity was monitored in an activity chamber 1 day before (baseline) and 5 days after osmotic mini-pump implantation, which allows continuous subcutaneous administration of saline or haloperidol (0.5 mg/kg/day). The radial maze playback paradigm was performed on day 7 (after osmotic mini-pump implantation). Gray bars indicate that 50-kHz USV playback (PB) was presented during 5 min