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Parental Depressive Feelings Parental Support and the Serotonin Transporter Gene as Predictors of Adolescent Depressive Feelings: A Latent Growth Curve Analysis

机译:父母抑郁情绪父母支持和5-羟色胺转运蛋白基因可预测青少年抑郁情绪:潜在生长曲线分析

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摘要

Parental support and parental depressive feelings are found to be associated with depressive feelings in adolescent boys and girls, but results are inconsistent. In addition, the 5-HTTLPR genotype has been found to interact with environmental stressors in predicting adolescents’ depressive feelings, but this has not been examined longitudinally. Therefore, the present study examined the relationships between parental support, parental depressive feelings, and adolescent depressive feelings. In addition, the relationships between the 5-HTTLPR genotype and adolescent depressive feelings were explored, as well as gene-environment interactions. Adolescents (N = 306; Girls = 53.3%; Mage T1 = 13.4) filled out questionnaires at five annual waves and provided saliva samples for DNA. Latent growth curve modelling (LGCM) was used to examine the baseline level and the change in depressive feelings over time. Maternal support was related to baseline levels of depressive feelings in girls, whereas paternal support was related to baseline levels in boys. Paternal depressive feelings were only related to boys’ depressive feelings at baseline, and maternal depressive feelings were not related to any outcome measures. Furthermore, no associations were found between 5-HTTLPR genotype and adolescent depressive feelings, and no gene-environment interactions emerged. Limitations of the study and implications of the findings are discussed.
机译:父母的支持和父母的压抑感被发现与青春期男孩和女孩的压抑感相关,但结果并不一致。此外,已发现5-HTTLPR基因型在预测青少年的抑郁感时与环境应激源相互作用,但尚未对此进行纵向检验。因此,本研究探讨了父母的支持,父母的抑郁感和青少年的抑郁感之间的关系。此外,还探讨了5-HTTLPR基因型与青少年抑郁感之间的关系,以及基因与环境之间的相互作用。青少年(N = 306;女孩= 53.3%;法师T1 = 13.4)在每年五次的调查中填写问卷,并提供唾液样本中的DNA。潜伏增长曲线模型(LGCM)用于检查基线水平和抑郁感随时间的变化。母亲的支持与女孩的抑郁感基线水平有关,而父亲的支持与男孩的抑郁感基线水平有关。父亲的压抑感仅与男孩在基线时的压抑感相关,而母亲的压抑感与任何结果指标均无关。此外,没有发现5-HTTLPR基因型与青少年抑郁感之间的关联,也没有出现基因与环境的相互作用。讨论了研究的局限性和发现的意义。

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