Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D 125-dihydroxyvitamin-D and prostate cancer: a nested case–control study

摘要

PurposeVitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer.