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Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies

机译：Sotatercept（ACE-011）在铂类化疗方案治疗转移性乳腺癌或晚期或转移性实体瘤患者中治疗化疗引起的贫血：两项2期研究的结果

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摘要

PurposeSotatercept may represent a novel approach to the treatment of chemotherapy-induced anemia (CIA). We report the results from two phase 2 randomized studies examining the use of sotatercept for the treatment of CIA in patients with metastatic cancer.

机译：目的Sotatercept可能代表了一种新型的化学疗法引起的贫血（CIA）的治疗方法。我们报告了两项2期随机研究的结果，这些研究检查了sotatercept在转移癌患者中治疗CIA的用途。

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期刊名称 Springer Open Choice
作者
Haralambos Raftopoulos; Abderrahmane Laadem; Paul J. Hesketh; Jerome Goldschmidt; Nashat Gabrail; Cynthia Osborne; Muhammad Ali; Matthew L. Sherman; Ding Wang; John A. Glaspy; Marie Puccio-Pick; Jun Zou; Jeffrey Crawford;
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年(卷),期 -1(24),-1
年度 -1
页码 1517–1525
总页数 9
原文格式 PDF
正文语种
中图分类外科学;
关键词
ActRIIA Chemotherapy-induced anemia Erythropoiesis Sotatercept;

机译：ActRIIA;化疗引起的贫血;红细胞生成;Sotatercept;

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专利

1. Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies [J] . Raftopoulos Haralambos, Laadem Abderrahmane, Hesketh Paul J., Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer . 2016,第4期

机译：Sotatercept（ACE-011）用于治疗转移性乳腺癌或已接受铂类化疗方案治疗的晚期或转移性实体瘤患者的化疗引起的贫血：两项2期研究的结果
2. Phase I Study of ONT-380, a HER2 Inhibitor, in Patients with HER2(+)-Advanced Solid Tumors, with an Expansion Cohort in HER2(+) Metastatic Breast Cancer (MBC) [J] . Moulder Stacy L., Borges Virginia F., Baetz Tara, Clinical cancer research: an official journal of the American Association for Cancer Research . 2017,第14期

机译：I阶段研究ont-380，HER2抑制剂，HER2（+）晚期实体瘤患者，HER2（+）转移乳腺癌（MBC）中的膨胀队列
3. Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study [J] . Dirix Luc Y., Takacs Istvan, Jerusalem Guy, Breast cancer research and treatment. . 2018,第3期

机译：Avelumab，一种抗PD-L1抗体，患有局部晚期或转移性乳腺癌的患者：1B标枪固体瘤研究
4. Phase I/II clinical trials on the effect of weekly paclitaxel (wPTX) and wPTX containing combination regimens for advanced and metastatic gastric cancer -ECRIN group studies [C] . Sakamoto J, Kodera Y, Kobayashi M, International Gastric Cancer Congress . 2009

机译：I / II期临床试验关于每周紫杉醇（WPTX）和WPTX含有晚期和转移性胃癌组合方案的临床试验 - 分泌组研究
5. A phase Ib study of safety and pharmacokinetics of trastuzumab emtansine and pertuzumab in Japanese patients with HER2-positive metastatic breast cancer [D] . NOGUCHI, Emi 2019

机译：Ib期研究曲妥珠单抗氨丹宁和帕妥珠单抗在日本HER2阳性转移性乳腺癌患者中的安全性和药代动力学
6. A phase I multicenter study of antroquinonol in patients with metastatic non-small-cell lung cancer who have received at least two prior systemic treatment regimens including one platinum-based chemotherapy regimen [O] . YU-CHIN LEE, CHING-LIANG HO, WOEI-YAU KAO, -1

机译：转移性非小细胞肺癌患者中至少一项先前的全身治疗方案（包括一种铂类化疗方案）中抗喹诺酮类药物的I期多中心研究
7. Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies [O] . 2016

机译：Sotatercept（ACE-011）在铂类化疗方案治疗转移性乳腺癌或晚期或转移性实体瘤患者中治疗化疗引起的贫血：两项2期研究的结果

Sotatercept (ACE-011) for the treatment of chemotherapy-induced anemia in patients with metastatic breast cancer or advanced or metastatic solid tumors treated with platinum-based chemotherapeutic regimens: results from two phase 2 studies

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