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Aryl-135-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen zymosan and lipopolysaccharide

机译：组胺H4受体的芳基-135-三嗪配体减弱了对角叉菜胶酵母聚糖和脂多糖的炎症和伤害感受

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摘要

Objective and designHistamine H4 receptor (H4R) offers a great potential for new therapeutic strategies for the treatment of inflammation-based diseases. The aim of this study is to present the pharmacological profile of two recently synthesized ligands of H4R with particular reference to their anti-inflammatory and analgesic activity.

机译：目的和设计组胺H4受体（H4R）为基于炎症的疾病的新治疗策略提供了巨大潜力。这项研究的目的是介绍两种最近合成的H4R配体的药理特性，特别是其抗炎和镇痛活性。

著录项

期刊名称 Springer Open Choice
作者
Szczepan Mogilski; Monika Kubacka; Dorota Łażewska; Małgorzata Więcek; Monika Głuch-Lutwin; Małgorzata Tyszka-Czochara; Karolina Bukowska-Strakova; Barbara Filipek; Katarzyna Kieć-Kononowicz;
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作者单位

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年(卷),期 -1(66),1
年度 -1
页码 79–95
总页数 17
原文格式 PDF
正文语种
中图分类外科学;
关键词
Histamine H4 receptor Inflammation Pain Edema Cytokine Triazine;

机译：组胺;H4受体;炎症;疼痛;浮肿;细胞因子;三嗪;

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专利

1. Development and chemistry of histamine H4 receptor ligands as potential modulators of inflammatory and allergic responses [J] . Venable J.D, Thurmond R.L Anti-Inflammatory & Anti-allergy Agents in Medicinal Chemistry . 2006,第4期

机译：组胺H4受体配体作为炎症和过敏反应的潜在调节剂的发展和化学
2. Development and Chemistry of Histamine H4 Receptor Ligands as Potential Modulators of Inflammatory and Allergic Responses [J] . J. D. Venable R. L. Thurmond Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents) . 2006,第4期

机译：组胺H4受体配体作为炎症和过敏反应的潜在调节剂的开发和化学。
3. Modulation of Tissue Inflammatory Response by Histamine Receptors in Scorpion Envenomation Pathogenesis: Involvement of H4 Receptor [J] . LamraouiA., Adi-BessalemS., Laraba-DjebariF. Inflammation . 2014,第5期

机译：组胺受体在蝎毒症发病机理中对组织炎症反应的调节：H4受体的参与。
4. Unraveling the Role of Histamine Receptors HI, H2, H3, and H4 in the Canine Gastrointestinal Tract [C] . Conference of the American College of Veterinary Internal Medicine (ACVIM) . 2017

机译：解开组胺受体HI，H 2，H3和H4在犬胃肠道中的作用
5. Didox modulates reactive oxygen species production and inflammatory events induced by lipopolysaccharide (LPS) and aryl hydrocarbon receptor (AHR) ligands in raw 264.7 murine macrophages. [D] . Matsebatlela, Thabe Moses. 2009

机译：Didox调节未加工的264.7鼠巨噬细胞中脂多糖（LPS）和芳烃受体（AHR）配体引起的活性氧的产生和炎症事件。
6. Histamine H4 receptor optimizes TR cell frequency and facilitates anti-inflammatory responses within the CNS [O] . Roxana del Rio, Rajkumar Noubade, Naresha Saligrama, -1

机译：组胺H4受体优化TR细胞的频率和促进CNs内抗炎应答
7. Aryl-1,3,5-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide [O] . Szczepan Mogilski, Monika Kubacka, Dorota Łażewska, 2016

机译：组胺H4受体的芳基-1,3,5-三嗪配体减弱了对角叉菜胶，酵母聚糖和脂多糖的炎症和伤害感受
8. Systemically Administered Histamine H1 and H2 Receptor Antagonists Do Not Blockthe ACTH Response to Bacterial Lipopolysaccharide and Interleukin-1 [R] . Perlstein, R. S. 1994

机译：全身给药的组胺H1和H2受体拮抗剂不会阻止aCTH对细菌脂多糖和白细胞介素-1的反应

Aryl-135-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen zymosan and lipopolysaccharide

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