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Systems for deep brain stimulation: review of technical features

机译:脑深部刺激系统:技术特点回顾

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摘要

The use of deep brain stimulation (DBS) is an important treatment option for movement disorders and other medical conditions. Today, three major manufacturers provide implantable systems for DBS. Although the underlying principle is basically the same for all available systems, the differences in the technical features vary considerably. This article outlines aspects regarding the technical features of DBS systems. The differences between voltage and current sources are addressed and their effect on stimulation is shown. To maintain clinical benefit and minimize side effects the stimulation field has to be adapted to the requirements of the patient. Shaping of the stimulation field can be achieved by the electrode design and polarity configuration. Furthermore, the electric signal consisting of stimulation rate, stimulation amplitude and pulse width affect the stimulation field. Interleaving stimulation is an additional concept, which permits improved treatment outcomes. Therefore, the electrode design, the polarity, the electric signal, and the concept of interleaving stimulation are presented. The investigated systems can be also categorized as rechargeable and non-rechargeable, which is briefly discussed. Options for interconnecting different system components from various manufacturers are presented. The present paper summarizes the technical features and their combination possibilities, which can have a major impact on the therapeutic effect.
机译:对于运动障碍和其他医学状况,使用深部脑刺激(DBS)是重要的治疗选择。如今,三大制造商为DBS提供了可植入系统。尽管所有可用系统的基本原理都相同,但是技术特征上的差异却很大。本文概述了有关DBS系统技术特性的各个方面。解决了电压源和电流源之间的差异,并显示了它们对刺激的影响。为了保持临床益处并最小化副作用,刺激场必须适应患者的需求。刺激场的成形可以通过电极设计和极性配置来实现。此外,由刺激速率,刺激幅度和脉冲宽度组成的电信号影响刺激场。交错刺激是另一个概念,可以改善治疗效果。因此,提出了电极设计,极性,电信号和交错刺激的概念。所研究的系统也可以分为可充电和不可充电,这将进行简要讨论。提供了用于互连来自不同制造商的不同系统组件的选项。本文总结了可能对治疗效果产生重大影响的技术特征及其组合可能性。

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