Population pharmacokinetics of nintedanib an inhibitor of tyrosine kinases in patients with non-small cell lung cancer or idiopathic pulmonary fibrosis

摘要

PurposeA population pharmacokinetic model was developed for nintedanib in patients with non-small cell lung cancer (NSCLC) or idiopathic pulmonary fibrosis (IPF). The effects of intrinsic and extrinsic patient factors on exposure of nintedanib and its main metabolite BIBF 1202 were studied.