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Volumetric and texture analysis of pretherapeutic 18F-FDG PET can predict overall survival in medullary thyroid cancer patients treated with Vandetanib

机译：治疗前18F-FDG PET的体积和质地分析可以预测接受Vandetanib治疗的甲状腺髓样癌患者的总体生存率

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摘要

PurposeThe metabolically most active lesion in 2-deoxy-2-(¹⁸F)fluoro-D-glucose (¹⁸F-FDG) PET/CT can predict progression-free survival (PFS) in patients with medullary thyroid carcinoma (MTC) starting treatment with the tyrosine kinase inhibitor (TKI) vandetanib. However, this metric failed in overall survival (OS) prediction. In the present proof of concept study, we aimed to explore the prognostic value of intratumoral textural features (TF) as well as volumetric parameters (total lesion glycolysis, TLG) derived by pre-therapeutic ¹⁸F-FDG PET.

机译：目的2- /脱氧-2-（^{18 F）氟-D-葡萄糖（^{18 F-FDG）PET / CT中代谢最活跃的病变可预测无进展生存期（PFS）在甲状腺髓样癌（MTC）患者中开始使用酪氨酸激酶抑制剂（TKI）vandetanib治疗。但是，该指标在总体生存（OS）预测中失败。在本概念验证研究中，我们旨在探讨治疗前^{18 F-FDG得出的肿瘤内纹理特征（TF）和体积参数（总病变糖酵解，TLG）的预后价值宠物。}}}

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期刊名称 Springer Open Choice
作者
Rudolf A. Werner; Ralph A. Bundschuh; Takahiro Higuchi; Mehrbod S. Javadi; Steven P. Rowe; Norbert Zsótér; Matthias Kroiss; Martin Fassnacht; Andreas K. Buck; Michael C. Kreissl; Constantin Lapa;
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作者单位

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年(卷),期 -1(63),2
年度 -1
页码 293–300
总页数 8
原文格式 PDF
正文语种
中图分类外科学;
关键词
Medullary thyroid carcinoma Tyrosine kinase inhibitor TKI Vandetanib sup18/supF-FDG Positron emission tomography 2-deoxy-2-(sup18/supF)fluoro-D-glucose Personalized medicine;

机译：甲状腺髓样癌;酪氨酸激酶抑制剂;TKI;Vandetanib;sup 18 / sup F-FDG;正电子发射断层扫描;2-deoxy-2-（sup 18 / sup F）氟-D-葡萄糖;个性化医学;

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专利

1. Volumetric and texture analysis of pretherapeutic 18F-FDG PET can predict overall survival in medullary thyroid cancer patients treated with Vandetanib [J] . Rudolf A. Werne Endocrine. . 2019,第2期

机译：Pretherapeutic 18F-FDG PET的体积和纹理分析可以预测麦克风甲状腺癌患者的整体存活率
2. Volumetric and texture analysis of pretherapeutic F-18-FDG PET can predict overall survival in medullary thyroid cancer patients treated with Vandetanib [J] . Werner Rudolf A., Bundschuh Ralph A., Higuchi Takahiro, Journal of neurosurgical sciences . 2019,第2期

机译：Pretherapeutic F-18-FDG PET的体积和纹理分析可以预测麦克风甲状腺癌患者的整体存活术治疗Vandetanib
3. Predictive Value of 18F-FDG PET in Patients with Advanced Medullary Thyroid Carcinoma Treated with Vandetanib [J] . Rudolf A. Werner, Jan-Stefan Schmid, Takahiro Higuchi, The Journal of Nuclear Medicine . 2018,第5期

机译：Vandetanib治疗18F-FDG PET在晚期甲状腺髓样癌患者中的预测价值
4. Prediction of Response and Prognosis by a Score Including Only Pretherapeutic Parameters in 410 Neoadjuvant Treated Gastric Cancer Patients [C] . Lorenzen Sylvie, Blank Susanne, Ott Katja St. Gallen EORTC Gastrointestinal Cancer Conference . 2012

机译：在410个新辅助治疗胃癌患者中仅包括Prethereic参数的分数预测响应和预后预测
5. Risk Factors of Salivary Gland Dysfunction in Radioiodine Treated Thyroid Cancer Patients and Automation of SPECT/CT Imaging Analysis of Mouse Thyroid [D] . Hollingsworth, Brynn Anne. 2017

机译：放射性碘治疗甲状腺癌患者唾液腺功能障碍的危险因素及小鼠甲状腺的SPECT / CT成像自动化
6. Radiomic Profiling of Head and Neck Cancer: 18F-FDG PET Texture Analysis as Predictor of Patient Survival [O] . G. Feliciani, F. Fioroni, E. Grassi, 2018

机译：头颈癌的放射学特征分析：18F-FDG PET纹理分析可预测患者生存率
7. Structural Doubling Time Predicts Overall Survival in Patients with Medullary Thyroid Cancer in Patients with Rapidly Progressive Metastatic Medullary Thyroid Cancer Treated with Molecular Targeted Therapies [O] . Tiffany Yeh, Michele Yeung, Eric J. Sherman, 2020

机译：结构倍增时间预测患有分子靶向疗法迅速进行转移髓质甲状腺癌患者髓质甲状腺癌的患者的整体存活

Volumetric and texture analysis of pretherapeutic 18F-FDG PET can predict overall survival in medullary thyroid cancer patients treated with Vandetanib

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