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A mathematical model for designing networks of C-Reactive Protein point of care testing

机译:设计C反应蛋白即时检验网络的数学模型

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摘要

One approach to improving antibiotic stewardship in primary care may be to support all General Practitioners (GPs) to have access to point of care C-Reactive Protein tests to guide their prescribing decisions in patients presenting with symptoms of lower respiratory tract infection. However, to date there has been no work to understand how clinical commissioning groups might approach the practicalities of system-wide implementation. We aimed to develop an accessible service delivery modelling tool that, based on open data, could generate a layout of the geographical distribution of point of care facilities that minimised the cost and travel distance for patients across a given region. We considered different implementation models where point of care tests were placed at either GP surgeries, pharmacies or both. We analysed the trade-offs between cost and travel found by running the model under different configurations and analysing the model results in four regions of England (two urban, two rural). Our model suggests that even under assumptions of short travel distances for patients (e.g. under 500m), it is possible to achieve a meaningful reduction in the number of necessary point of care testing facilities to serve a region by referring some patients to be tested at nearby GP surgeries or pharmacies. In our test cases pharmacy-led implementation models resulted in some patients having to travel long distances to obtain a test, beyond the desired travel limits. These results indicate that an efficient implementation strategy for point of care tests over a geographic region, potentially building on primary care networks, might lead to significant cost reduction in equipment and associated personnel training, maintenance and quality control costs; as well as achieving fair access to testing facilities.
机译:改善初级保健中抗生素管理的一种方法可能是支持所有普通科医生(GP)获得护理点C反应蛋白测试,以指导出现下呼吸道感染症状的患者做出处方决定。但是,迄今为止,还没有任何工作来了解临床调试小组如何处理系统范围内实施的实用性。我们旨在开发一种可访问的服务交付建模工具,该工具基于开放数据,可以生成护理点设施的地理分布布局,从而使给定区域内患者的成本和旅行距离最小化。我们考虑了将GP手术,药房或两者同时进行的现场测试的不同实施模型。通过分析在不同配置下运行该模型并分析英格兰四个地区(两个城市,两个农村)的模型结果,我们分析了成本与旅行之间的权衡。我们的模型表明,即使假设患者的旅行距离较短(例如,在500m以下),也可以通过转诊附近的一些患者来有意义地减少服务于该地区的必要的护理点测试设施的数量。全科医生手术或药房。在我们的测试案例中,以药房为主导的实施模型导致一些患者必须长途跋涉才能获得测试,超出了预期的旅行限制。这些结果表明,有效的实施策略可能会建立在初级保健网络上,在一个地理区域内进行即时检验,可能会显着降低设备成本以及相关的人员培训,维护和质量控制成本;以及公平使用测试设施。

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