Efficacy and safety of sequential versus quadruple therapy as second-line treatment for helicobacter pylori infection—A randomized controlled trial

摘要

Background and aimsQuadruple therapy is recommended as second-line treatment for Helicobacter pylori eradication failure. However, high cost, multiple side effects, and low adherence rates are major drawbacks to its routine use. Our aim was to compare the efficacy and safety of sequential versus quadruple regimens as second line treatment for persistent Helicobacter pylori infection.