A simulation study on the impact of the blood flow-dependent component in [18F]AV45 SUVR in Alzheimer’s disease

摘要

BackgroundIncreased brain uptake on [¹⁸F]AV45 PET is a biomarker for Alzheimer’s disease (AD). The standardised uptake value ratio (SUVR) is widely used for quantification but is subject to variability. Here we evaluate how SUVR of a cortical target region is affected by blood flow changes in the target and two frequently used reference regions.