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Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance

机译：慢性奥氮平治疗引起Balb / c小鼠血浆脂肪酸谱的紊乱：奥氮平诱导的胰岛素抵抗的潜在机制

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BackgroundAtypical antipsychotics such as olanzapine cause metabolic side effects leading to obesity and insulin resistance. The underlying mechanisms remain elusive. In this study we investigated the effects of chronic treatment of olanzapine on the fatty acid composition of plasma in mice.

机译：背景非典型的抗精神病药，例如奥氮平会引起代谢性副作用，从而导致肥胖和胰岛素抵抗。潜在的机制仍然难以捉摸。在这项研究中，我们研究了奥氮平的慢性治疗对小鼠血浆脂肪酸组成的影响。

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期刊名称 PLoS Clinical Trials
作者
Huqun Li; Maosheng Fang; Mingzhen Xu; Shihong Li; Juan Du; Weiyong Li; Hui Chen;
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年(卷),期 2011(11),12
年度 2011
页码 e0167930
总页数 13
原文格式 PDF
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专利

1. Olanzapine treatment is associated with reduced high molecular weight adiponectin in serum: a potential mechanism for olanzapine-induced insulin resistance in patients with schizophrenia. [J] . Richards AA, Hickman IJ, Wang AY, Journal of clinical psychopharmacology . 2006,第3期

机译：奥氮平治疗与降低血清中的高分子量脂联素有关：奥氮平诱导的精神分裂症患者胰岛素抵抗的潜在机制。
2. Chronic treatment with the modified Longdan Xiegan Tang attenuates olanzapine-induced fatty liver in rats by regulating hepatic de novo lipogenesis and fatty acid beta-oxidation-associated gene expression mediated by SREBP-1c, PPAR-alpha and AMPK-alpha [J] . Ren Liying, Sun Dongmei, Zhou Xia, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2019,第期

机译：通过调节Srebp-1c，PPAR-α和AMPK-α介导的肝脏DE Novo脂肪生成和脂肪酸β-氧化相关基因表达，通过调节龙丹Xiegan唐的慢性治疗衰减大鼠奥丹滨诱导的脂肪肝
3. Olanzapine-induced weight gain: Chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution. [J] . van-der-Zwaal EM, Luijendijk MC, Adan RA, European Journal of Pharmacology: An International Journal . 2008,第1期

机译：奥氮平引起的体重增加：由于溶液中奥氮平的降解，使用渗透性微型泵的长期输注不能产生稳定的血浆水平。
4. The effect of different treatments for early lactation hyperketonemia on blood G-hydroxybutyrate, plasma non-esterified fatty acids, glucose, insulin, and glucagon in dairy cattle [C] . Annual Conference of the American Association of Bovine Practitioners . 2017

机译：早期哺乳期血液对血液G-羟基丁酯，血浆非酯化脂肪酸，葡萄糖，胰岛素和血糖素在乳制品中的影响
5. The mechanisms underlying free fatty acid-induced hepatic insulin resistance. [D] . Park, Kyu Yol Edward. 2008

机译：游离脂肪酸诱导的肝胰岛素抵抗的潜在机制。
6. Unraveling the Mechanisms Underlying Olanzapine-Induced Insulin Resistance [O] . Nigel Irwin, Victor Alan Gault 2013

机译：阐明奥氮平诱导的胰岛素抵抗的潜在机制
7. Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance. [O] . Huqun Li, Maosheng Fang, Mingzhen Xu, 2016

机译：慢性奥氮平治疗诱导Balb / c小鼠血浆脂肪酸谱的紊乱：奥氮平诱导胰岛素抵抗的潜在机制。

Chronic Olanzapine Treatment Induces Disorders of Plasma Fatty Acid Profile in Balb/c Mice: A Potential Mechanism for Olanzapine-Induced Insulin Resistance

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