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Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients

机译：肝细胞癌中神经降压素/ IL-8通路功能异常激活与微环境中的炎症反应增加，癌症中的上皮间质转化和患者预后更差相关

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AimTo investigate the role of neurotensin (NTS) in hepatocellular carcinoma (HCC) sub- grouping and the clinical and pathological significance of activation of NTS/IL-8 pathway in HCC.

机译：目的探讨神经降压素（NTS）在肝细胞癌（HCC）分组中的作用以及在肝癌中激活NTS / IL-8途径的临床和病理学意义。

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期刊名称 PLoS Clinical Trials
作者
Jinpu Yu; Xiubao Ren; Yongzi Chen; Pengpeng Liu; Xiyin Wei; Hui Li; Guoguang Ying; Kexin Chen; Hans Winkler; Xishan Hao;
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年(卷),期 2010(8),2
年度 2010
页码 e56069
总页数 15
原文格式 PDF
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专利

1. Neurotensin/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells [J] . Pei Xiao, Xinxin Long, Lijie Zhang, Oncoimmunology. . 2018,第7期

机译：Neurotensin / IL-8途径通过诱导肿瘤相关巨噬细胞的M2偏振和肝细胞癌细胞的上皮 - 间充质转换来衡量局部炎症反应和肿瘤侵袭
2. Predictive value of intratumour inflammatory cytokine mRNA levels of hepatocellular carcinoma patients and activation of two distinct pathways govern IL-8 induced epithelial-mesenchymal transition in human hepatic cancer cell lines [J] . Peng Siqi, Chen Yutong, Gong Yihang, Cytokine . 2019,第期

机译：肝细胞癌患者肿瘤炎症细胞因子mRNA水平的预测值和两个明显途径的激活治理IL-8诱导人肝癌细胞系中的上皮 - 间充质转换
3. Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway [J] . Xiu-Tao Fu, Zhi Dai, Kang Song, International journal of oncology . 2014,第2期

机译：巨噬细胞分泌的IL-8通过激活JAK2 / STAT3 / Snail途径诱导肝癌细胞上皮-间质转化
4. ROLE OF CD36 AND FREE FATTY ACID UPTAKE IN EPITHELIAL-MESENCHYMAL TRANSITION OF HEPATOCELLULAR CARCINOMA CELLS [C] . Christina Chan Biochemical and molecular engineering XX: the next generation of biochemical engineering: from nanoscale to industrial scale . 2017

机译：CD36和游离脂肪酸摄取在肝癌细胞上皮间质转化中的作用
5. Targeting the MEK5, MEK1/2, and/or Pi3k Pathways Reverses Epithelial to Mesenchymal Transition and Enhances Chemotherapeutic Sensitivity in Breast and Brain Cancers with a Mesenchymal Phenotype [D] . Bhatt, Akshita B. 2021

机译：靶向MEK5，MEK1 / 2和/或PI3K途径将上皮细胞转型的上皮性反转，并通过间充质表型提高乳腺癌和脑癌中的化疗敏感性
6. Neurotensin/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells [O] . Pei Xiao, Xinxin Long, Lijie Zhang, 2018

机译：Neurotensin / IL-8途径通过诱导肿瘤相关巨噬细胞的M2极化和肝癌细胞的上皮-间质转化来协调局部炎症反应和肿瘤侵袭
7. Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients. [O] . Jinpu Yu, Xiubao Ren, Yongzi Chen, 2013

机译：肝细胞癌中神经降压素/ IL-8途径的功能失活激活与微环境中的炎症反应增加，癌症中更多的上皮间质转化和患者的更差预后相关。

Dysfunctional Activation of Neurotensin/IL-8 Pathway in Hepatocellular Carcinoma Is Associated with Increased Inflammatory Response in Microenvironment, More Epithelial Mesenchymal Transition in Cancer and Worse Prognosis in Patients

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