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The Role of Age and Exposure to Plasmodium falciparum in the Rate of Acquisition of Naturally Acquired Immunity: A Randomized Controlled Trial

机译:年龄和暴露于恶性疟原虫在自然获得性免疫获得率中的作用:随机对照试验。

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摘要

BackgroundThe rate of acquisition of naturally acquired immunity (NAI) against malaria predominantly depends on transmission intensity and age, although disentangling the effects of these is difficult. We used chemoprophylaxis to selectively control exposure to P. falciparum during different periods in infancy and explore the effect of age in the build-up of NAI, measured as risk of clinical malaria.
机译:背景对抗疟疾的自然获得性免疫(NAI)的获得率主要取决于传播强度和年龄,尽管难以区分这些效应。我们使用化学预防措施来选择性地控制婴儿期不同时期对恶性疟原虫的暴露,并探讨了年龄对NAI累积的影响,以临床疟疾风险衡量。

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