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RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity

机译：基于RNAi的筛选确定干扰二恶英介导的CYP1A1活性上调的激酶。

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BackgroundThe aryl hydrocarbon receptor (AhR) is a transcription factor activated by several environmental pollutants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and involved in carcinogenesis and various physiological processes, including immune response and endocrine functions. Characterization of kinases-related AhR transduction pathway remains an important purpose.

机译：背景芳烃受体（AhR）是一种转录因子，可被2,3,7,8-四氯二苯并-p-二恶英（TCDD）等几种环境污染物激活，并参与致癌作用和各种生理过程，包括免疫应答和内分泌功能。激酶相关的AhR转导途径的表征仍然是重要的目的。

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期刊名称 PLoS Clinical Trials
作者
David Gilot; Nolwenn Le Meur; Fanny Giudicelli; Marc Le Vée; Dominique Lagadic-Gossmann; Nathalie Théret; Olivier Fardel;
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年(卷),期 2011(6),3
年度 2011
页码 e18261
总页数 10
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专利

1. RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors [J] . S Morgan-Lappe, K W Woods, Q Li, Oncogene . 2006,第9期

机译：基于RNAi的人类激酶组筛选可识别Akt协同激酶：一种设计有效的多靶点激酶抑制剂的新方法
2. High Throughput Short Interfering RNA (siRNA) Screening of the Human Kinome Identifies Novel Kinases Controlling the Canonical Nuclear Factor-κB (NF-κB) Activation Pathway [J] . Sanjeev Choudhary, Kevin P. Rosenblatt, Ling Fang, The Journal of biological chemistry . 2011,第43期

机译：人Kinome的高吞吐量短干扰RNA（siRNA）筛选人Kinome鉴定了控制规范核因子-κB（NF-κB）活化途径的新型激酶
3. Screening of protein kinase inhibitors and knockdown experiments identified four kinases that affect mitochondrial ATP synthesis activity [J] . SugawaraK., FujikawaM., YoshidaM. FEBS letters. . 2013,第23期

机译：蛋白激酶抑制剂的筛选和敲除实验确定了影响线粒体ATP合成活性的四种激酶
4. Determination of relative affinity and inhibitory activity of pyrazolone analogs using Mycobacterium tuberculosis shikimate kinase LC-MS based screening assays [C] . Vanisree Mulabagal, Angela I. Calderon American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：基于分枝杆菌的吡唑酮类似物的相对亲和力和抑制活性测定基于筛选激酶LC-MS的筛选测定
5. RNAi High Throughput Screenings Facilitate the Identification of Proteins Necessary for TCDD-induced CYP1A1 Enzymatic Activity and Aid in the Discovery of a Novel Role for Sin3A in AHR-Mediated Gene Expression [D] . Solaimani, Parrisa Sherry 2012

机译：RNAi高通量筛选有助于识别TCDD诱导的CYP1A1酶活性和在AHR介导的基因表达中Sin3A的新型作用发现中的帮助所需的蛋白质
6. Kinome-Wide Screening with Small Interfering RNA Identified Polo-like Kinase 1 as a Key Regulator of Proliferation in Oral Cancer Cells [O] . Yih-Gang Goan, Pei-Feng Liu, Hsueh-Wei Chang, 2019

机译：用小干扰RNA的全基因组筛选将Polo样激酶1鉴定为口腔癌细胞增殖的关键调节剂。
7. RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity [O] . Gilot, David, Le Meur, Nolwenn, Giudicelli, Fanny, 2011

机译：基于RNAi的筛选确定干扰二恶英介导的CYP1A1活性上调的激酶。
8. Identifying Physiological Substrates of the Snf-1-Related Kinase Hunk: New Biomarkers of Kinase Activity and Therapeutic Targets in Metastatic Breast Cancer. [R] . Bieberich, C. J. 2011

机译：鉴定snf-1相关激酶Hunk的生理基质：转移性乳腺癌激酶活性和治疗靶点的新生物标志物。

RNAi-Based Screening Identifies Kinases Interfering with Dioxin-Mediated Up-Regulation of CYP1A1 Activity

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