Effects of Genetic Variants in ADCY5 GIPR GCKR and VPS13C on Early Impairment of Glucose and Insulin Metabolism in Children

摘要

ObjectiveRecent genome-wide association studies identified novel candidate genes for fasting and 2 h blood glucose and insulin levels in adults. We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children.